| 发明名称 |
POLYPEPTIDE CONSTRUCTS AND USES THEREOF |
| 摘要 |
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen. |
| 申请公布号 |
US2014248238(A1) |
申请公布日期 |
2014.09.04 |
| 申请号 |
US201414262841 |
申请日期 |
2014.04.28 |
| 申请人 |
Teva Pharmaceuticals Australia Pty Ltd |
发明人 |
Wilson, JR. David S.;Pogue Sarah L.;Mikesell Glen E.;Taura Tetsuya;Korver Wouter;Doyle Anthony G.;Clarke Adam;Pollard Matthew;Tran Stephen;Lin Jack Tzu Chiao |
| 分类号 |
C07K16/28;C07K14/565;C07K14/56;C07K14/57 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide construct, comprising an interferon (IFN) linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen,
wherein the IFN comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen. |
| 地址 |
Macquarie Park AU |
