Liposomal Vaccine Compositions Comprising a Polysaccharide Antigen and a Protein Adjuvant

摘要

A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against Haemophilus influenzae, Streptococcus pneumoniae or Neisseria meningitidis.

主权项

1. A liposomal composition comprising one or more polysaccharide antigens and a protein carrier coentrapped within liposomes;
wherein the one or more polysaccharide antigens are water-soluble; wherein the protein carrier has at least one T-cell epitope, a molecular weight of at least 35 kDa, and is non-toxic; wherein the polysaccharide antigen and protein carrier are non-conjugated; and wherein the liposomes have an average diameter in the range of 50 nm to 700 nm and are formed from liposome forming compounds that have, in combination, no overall ionic charge and comprise at least one phospholipid.