COMPOSITIONS OF MULTICATIONIC DRUGS FOR REDUCING INTERACTIONS WITH POLYANIONIC BIOMOLECULES AND METHODS OF USE THEREOF

摘要

The present invention relates, in part, to a composition comprising a multicationic drug and an organic multianion. In some embodiments, the multicationic drug is enclosed within a carrier. In some embodiments, the carrier is a liposome. In some embodiments, the multicationic drug and organic multianion are enclosed within a carrier, while in other embodiments, the multicationic drug is enclosed within the carrier and the organic multianion is outside the carrier. The present invention also relates, in part, to a method of treating a subject for pulmonary distress comprising administering to a subject in need thereof the aforementioned composition.

主权项

1. A composition comprising a multicationic aminoglycoside enclosed within a liposome and an organic multianion outside the liposome in close proximity to the aminoglycoside to allow for the formation of an aminoglycoside-counter ion complex upon release of the aminoglycoside from the interior of the liposome, wherein the organic multianion reduces binding of the aminoglycoside to a polyanionic biofilm associated with a pulmonary disease, and
an inhalation device.