| 发明名称 |
PRE-FUSION RSV F ANTIGENS |
| 摘要 |
The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F. |
| 申请公布号 |
US2014248314(A1) |
申请公布日期 |
2014.09.04 |
| 申请号 |
US201214117588 |
申请日期 |
2012.05.14 |
| 申请人 |
Swanson Kurt;Carfi Andrea |
发明人 |
Swanson Kurt;Carfi Andrea |
| 分类号 |
C07K14/005 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pre-fusion respiratory syncytial virus (RSV) F polypeptide comprising at least two introduced cysteine residues, wherein said cysteines are in close proximity to one another and form an intrachain disulfide bond that stabilizes the pre-fusion RSV F polypeptide. |
| 地址 |
Newton MA US |
