| 主权项 |
1. A compound having a structure of Formula I: or a pharmaceutically acceptable salt thereof, wherein:G is a linear, branched or non-aromatic cyclic, substituted or unsubstituted, saturated or unsaturated C1-C20 alkyl, wherein one or more carbon atoms of the C1-C20 alkyl may optionally be replaced with an oxygen atom;
a is 0 or 1; R1 and R2 are each independently H or linear or branched, substituted or unsubstituted, saturated or unsaturated C1-C10 alkyl, or R1 and R2 together may form a substituted or unsubstituted, saturated or unsaturated cyclic C3-C10 alkyl; R3, R4, R5 and R6 are each independently H, halo or linear or branched, substituted or unsubstituted, saturated or unsaturated C1-C10 alkyl; Q is J is G1, O, CH2, CHG1, CG12, S, NH, NG1, SO, SO2, or NR; M is H, OH, F, Cl, Br, CH2OH, CH2F, CH2Cl, CHCl2, CCl3, CH2Br, CHBr2 or CBr3; L is H, A-D or —CH2-A-D; A is O, S, NH, NG1, N+H2, or N+HG1; D is H, G1, R, or a moiety from TABLE 1; R is C1-C10 acyl; n is 0, 1, 2, 3, 4, 5, 6, 7 or 8; L2 is H or A2-D2; A2 is O, S, SO, SO2, NH, NG1, N+H2 or N+HG1; D2 is H, G1, R7, or a moiety from TABLE 1; G1 is a linear or branched, aromatic or non-aromatic cyclic, substituted or unsubstituted, saturated or unsaturated C2-C10 alkyl, and wherein the optional substituents for any of the C1-C20 alkyl, C1-C10 alkyl and cyclic C3-C10 alkyl moieties are each independently oxo, OR8, COOH, R9, OH, OR9, F, Cl, Br, I, NH2, NHR9, N(R9)2, CN, SH, SR9, SO3H, SO3R9, SO2R9, OSO3R9, OR, CO2R9, CONH2, CONHR9, CONHR, CON(R9)2, NHR, OPO3H3, CONR9R, NR9R or NO2, wherein R8 is a moiety from TABLE 1 and each R9 is independently unsubstituted C1-C10 alkyl, wherein the use is for modulating androgen receptor (AR) activity; provided that M is not CH2Cl when G is isopropyl and L is not H when G is a saturated C1-C20 alkyl, wherein one or more carbon atoms of the saturated C1-C20 alkyl have been replaced with an oxygen atom. |
