发明名称 |
SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER |
摘要 |
The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C-H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7- membered cyclic secondary amines) by reacting an azide that bears one or more C-H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines. |
申请公布号 |
WO2014134141(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
WO2014US18623 |
申请日期 |
2014.02.26 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
BETLEY, THEODORE, ALEXANDER;HENNESSY, ELISABETH, THERESE |
分类号 |
C07C209/02 |
主分类号 |
C07C209/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|