C:/NRPorbl/DCC/DX1/383H734_LDOC-8/26/201I1 The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression. WO 2005/112970 PCT/US2005/016798 A- 0 1 2 34 56 78 DAY AFTER LPS Fig. 2A '3 -pGSN .8- -I-SAUINE A- _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 01 23 45 67 8 DAY AFTER CIP Fig. 2B