MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide novel monospecific and bispecific antibodies which are useful as anti-neoplastic agents and which are specifically bound to human IGF-1R and human ErbB3.SOLUTION: The invention relates to a polyvalent bispecific antibody (PBA), which antibody is a protein comprising two pairs of polypeptide chains, each pair of the two pairs comprising a heavy chain joined to a light chain by at least one heavy-light chain bond; wherein each pair comprises at least one anti-IGF-1R binding site and at least one anti-ErB3 binding site; and each pair comprises a first binding site that comprises an N-terminal portion of the heavy chain of the PBA and an N-terminal portion of the light chain of the PBA, and a second binding site that is a C-terminal scFv that is entirely comprised by the heavy chain of the PBA, the C-terminal scFv containing a heavy chain variable region joined to a light chain variable region by a scFv linker.