摘要 |
Disclosed are lipidomimetic compounds of formula I
wherein:
G represents a group satisfying formula II:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ HO-CH 2 -{CH(OH)-CH 2 -O} p -CH 2 -{C(=O)-O-CH 2 } q- €ƒ€ƒ€ƒ€ƒ€ƒformula II
each n independently is an integer from 1-30;
p is an integer from 1-10;
q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37°C, and retarding clearance from circulation. |