COMPOSITIONS FOR USE AS OR IN WOUND DRESSINGS

摘要

The present invention provides a composition for the treatment of a wound, the composition comprising:
a first layer, which comprises a porous, optionally hydrophilic material capable of absorbing fluid from the wound at least in part by capilliary action,a second layer comprising an absorbent hydrogel, the first layer being associated with the second layer,wherein, in the treatment, the first layer is disposed closer to the wound than the second layer and the composition modulates the concentration of dissolved ions in the fluid in the wound. The present invention further provides uses of the composition and methods of making the composition.

主权项

1. A method of increasing the concentration of dissolved ions and modulating the concentration of dissolved potassium ions in a fluid in a chronic ulcerous skin lesion to treat the chronic ulcerous skin lesion, the method comprising contacting the fluid with a composition comprising with a composition comprising
a first layer, which comprises a porous, hydrophilic foamed material and/or a porous hydrophilic, fibrous material capable of absorbing the fluid at least in part by capilliary action, a second layer comprising an absorbent hydrogel, the first layer being associated with the second layer, wherein the hydrogel of the second layer comprises a hydrophilic polymer carrying multiple pendant sulphonyl groups on each polymer molecule, wherein in the hydrophilic polymer at least some of the pendant sulphonyl groups are present in salt form, sodium and potassium countercations being present in the hydrogel associated with the pendant groups, the molar ratio of sodium ions to potassium ions in the hydrogel composition to be in the range of between about 100:0.1 and about 100:10 and wherein, on initial contact of the composition with the fluid, the first layer is disposed closer to the liquid than the second layer.