发明名称 |
STX2-INHIBITING TETRAVALENT PEPTIDES AND THERAPEUTIC AGENTS COMPRISING STX2-INHIBITING TETRAVALENT PEPTIDES |
摘要 |
<p>PROBLEM TO BE SOLVED: To provide new inhibiting peptides targeting globotriose-binding site of B subunit of Stx2d and Stx2c to inhibit toxicity of Shiga toxin (Stx) of enterohemorrhagic E. coli.SOLUTION: The therapeutic agent for enterohemorrhagic E. coli infection is a Stx2-inhibiting tetravalent peptide having such a structure that respective 4 terminal amino residues of a molecular core structure comprised of chemically bonded 3 lysines are conjugated to one peptide motif species selected from MMMRRRR, LMARRRR, MMVRRRR, MMSRRRR, QMARRRR and IMARRRR directly or via a spacer.</p> |
申请公布号 |
JP2014159414(A) |
申请公布日期 |
2014.09.04 |
申请号 |
JP20140013815 |
申请日期 |
2014.01.28 |
申请人 |
DOSHISHA;OSAKA PREFECTURE UNIV |
发明人 |
NISHIKAWA KIYOTAKA;TAKAHASHI MIHO;MITSUI TAKAAKI;SHIMIZU HIDEKO;YAMAZAKI SHINJI |
分类号 |
C07K14/00;A61K38/00;A61P1/04;A61P31/04 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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