COMPOSITIONS AND METHODS FOR THE TREATMENT OF CNS INJURIES

摘要

The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective amount of glycosaminoglycan degrading enzyme. The glycosaminoglycan degrading enzyme may be dermatan sulfate or chondroitin sulfate degrading enzymes. The central nervous system contusion injury may include a traumatic brain injury or a spinal cord injury. The functional recovery may include autonomic functions, sensory functions, motor functions or the like.

主权项

1. A method of improving autonomic function comprising administering chondroitinase ABCType1 enzyme to a mammal following a contusion injury that led to an impairment of autonomic function to the central nervous system, wherein the autonomic function is improved.