发明名称 |
METHOD FOR PREDICTING RESPONSIVENESS TO COMPOUND INHIBITING MAPK SIGNAL TRANSDUCTION PATHWAY |
摘要 |
Provided are a method for predicting sensitivity to a molecularly targeted drug, a method for selecting patients for which administration of the drug is determined to have a high probability of success, and a reagent used in said methods. Specifically provided are: a method for using a biological sample derived from a cancer patient in order to predict responsiveness to cancer treatment by a compound that inhibits the mitogen-activated protein kinase (MAPK) signal transduction pathway, said method being characterized by measuring whether &bgr;-catenin in the biological sample has at least one mutation selected from the group consisting of (i) an activating mutation and (ii) a mutation in which an aspartic acid residue is substituted by a serine residue at the 287 position; a method for selecting a subject for cancer treatment using said compound; a cancer treatment method that includes administering the compound to a patient selected by the aforementioned method; and a reagent used in said methods. |
申请公布号 |
WO2014133071(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
WO2014JP54846 |
申请日期 |
2014.02.27 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
KIGA,MASAKI |
分类号 |
C12N15/09;A61K45/00;A61P35/00;A61P43/00;C07K16/18;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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