CO-ADMINISTRATION OF ATORVASTATIN AND ETHYL EICOSAPENTAENOIC ACID OR A DERIVATIVE THEREOF

摘要

In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing triglycerides in a subject on atorvastatin therapy, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.

主权项

1. A pharmaceutical composition comprising atorvastatin, the composition providing a mean steady state plasma Cmax, a mean steady state plasma AUC0-24, and/or a mean steady state plasma Tmax of atorvastatin of about 70% to about 135%, when co-administered with about 2 g or about 4 g per day of ethyl eicosapentaenoate, of a mean steady state plasma Cmax, a mean steady state plasma AUC0-24, and/or a mean steady state plasma Tmax of atorvastatin provided by a second pharmaceutical composition comprising atorvastatin administered without the ethyl eicosapentaenoate.