Method For Selecting Mevalonate Synthesis Modulators Using Cells Derived From Human Pluripotent Cells

摘要

A method for selecting pharmaceutical compounds affecting mevalonate or cholesterol, having a step for putting into contact with the pharmaceutical compounds to be tested, cells of the MSC type obtained by a method for producing cells of the MSC type from human pluripotent cells or from induced stem cells, including a step for cultivating human pluripotent cells or induced stem cells in a culture medium having the steps of: 1) One or more growth factors selected from FGFs, HGF, PDGFs, EGF, herugulins and VEGFs, and 2) One or more antioxidants selected from ascorbic acid and its derivatives, vitamin E and N-acetylcysteine.

主权项

1. A method for selecting pharmaceutical compounds enhancing for the effects of the inhibition of the synthesis of mevalonate, wherein the selected compounds can enhance cell toxicity in the presence of inhibitors of the synthesis of mevalonate comprising a step for contacting the cells with the pharmaceutical compounds to be tested, wherein the cells are obtained by a method for producing cells of the MSC type from human pluripotent cells or from induced stem cells.