发明名称 |
MIRNA PROFILING COMPOSITIONS AND METHODS OF USE |
摘要 |
Disclosed herein is a nanosensor of miRNA activity in a target cell, and methods of use, for detection and diagnostic applications. The nanosensor comprises a delivery particle comprising an iron oxide crystal coated with a polymer; and a sensor oligonucleotide covalently attached to the polymer. The sensor oligonucleotide comprises a seed region, comprising a nucleic acid sequence that is completely complementary to the target miRNA and comprises a cleavage site which can be engaged and cleaved by the target miRNA. |
申请公布号 |
WO2014134144(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
WO2014US18628 |
申请日期 |
2014.02.26 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
MOORE, ANNA V.;MEDAROVA, ZDRAVKA |
分类号 |
A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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