RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY

摘要

This invention relates to a viral vector encoding a recombinant factor VIII and a cell genetically engineered to produce a recombinant factor VIII, wherein said recombinant factor VIII comprises one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa, wherein the one or more mutations comprise substitution of one or more charged amino acid residues with a hydrophobic amino acid residue at either or both of the A1A2 or A2A3 domain interfaces.