A MODIFIED EFFECTOR CELL (OR CHIMERIC RECEPTOR) FOR TREATING DISIALOGANGLIOSIDE Gp2-EXPRESSING NEOPLASIA

摘要

A modified effector cell includes a non-reversibly produced vector-encoded anti-GD2-BB-ζ chimeric receptor for use in disialoganglioside GD2-expressing neoplasia, which is inserted in the cell, to obtain an effector cell that stably produces the anti-GD2-BB-ζ chimeric receptor, the chimeric receptor having two distinct mutually fused portions, i.e. an intra-cytoplasmic portion and an extra-cytoplasmic portion.