发明名称 |
BIOCOMPATIBLE AGENT FOR DISPERSING NANOPARTICLES INTO AN AQUEOUS MEDIUM USING MUSSEL ADHESIVE PROTEIN-MIMETIC POLYMER |
摘要 |
Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium. |
申请公布号 |
EP2658896(A4) |
申请公布日期 |
2014.09.03 |
申请号 |
EP20110852486 |
申请日期 |
2011.12.28 |
申请人 |
HANWHA CHEMICAL CORPORATION |
发明人 |
HYEON, TAEGHWAN;NA, KUN;LING, DAISHUN;PARK, WOORAM |
分类号 |
C08G73/00;A61K49/06;A61K49/18;C08G65/08;C08G73/02;C08G73/04;C08G81/02;C08L71/02 |
主分类号 |
C08G73/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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