发明名称 |
HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines |
摘要 |
The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B. |
申请公布号 |
EP2757109(A3) |
申请公布日期 |
2014.09.03 |
申请号 |
EP20140164544 |
申请日期 |
2008.05.27 |
申请人 |
ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC |
发明人 |
VAN DER BURG, SJOERD HENRICUS;KENTER, GEMMA G.;MELIEF, CORNELIS JOHANNES MARIA |
分类号 |
C07K14/005;A61K38/16;A61K39/12 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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