| 发明名称 | Monoclonal antibodies that bind B7H6 and uses thereof | ||
| 摘要 | Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells. | ||
| 申请公布号 | US8822652(B2) | 申请公布日期 | 2014.09.02 |
| 申请号 | US201013515276 | 申请日期 | 2010.12.08 |
| 申请人 | Institut National de la Sante et de la Recherche Medicale | 发明人 | Pierres Michel;Vivier Eric;Baratin Myriam |
| 分类号 | C07K16/28;A61K39/395 | 主分类号 | C07K16/28 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;DiGiorgio Jeanne M. |
| 主权项 | 1. An isolated monoclonal antibody, or antigen binding portion thereof, that binds to the same epitope on human B7H6 as an antibody produced by the hybridoma of clone designation number 4E5.5 (Deposit No. CNCM I-4242) or number 17B1.3 (Deposit No. CNCM I-4245). | ||
| 地址 | Paris FR | ||