发明名称 Substituted biaryl alkyl amides
摘要 Disclosed herein are substituted biaryl alkyl amide compounds, methods of synthesizing substituted biaryl alkyl amide compounds and methods of treating diseases and/or conditions with substituted biaryl alkyl amide compounds.
申请公布号 US8822527(B2) 申请公布日期 2014.09.02
申请号 US201213653115 申请日期 2012.10.16
申请人 Biotheryx, Inc. 发明人 Chan Kyle W. H.;Mercurio Frank;Stirling David I.
分类号 C07C233/63;C07C235/12;C07C237/12;C07D207/16;C07D307/24 主分类号 C07C233/63
代理机构 Knobbe Martens Olson & Bear LLP 代理人 Knobbe Martens Olson & Bear LLP
主权项 1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: n is selected from the group consisting of 0, 1, 2, 3, 4, and 5; each R1 is independently selected from the group consisting of halo, cyano, and azido; Z1, Z2, Z3, and Z4 are each independently —CH—; R2 is selected from the group consisting of an optionally substituted (C2-6 alkoxy)C1-6 alkyl, an optionally substituted C6-10 aryl, an optionally substituted (aryloxy)C1-6 alkyl, an optionally substituted pyrrolidinyl, an optionally substituted C3-7 cycloalkyl, an optionally substituted haloalkyl, and an optionally substituted aminoalkyl; R3 is —OH; R4 is R5 is —OH; R6 is selected from the group consisting of —OH, —NHR7, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 alkoxy, an optionally substituted C6-10 aryl, an optionally substituted aryloxy, and an optionally substituted arylalkoxy; R7 is hydrogen or an optionally substituted C1-6 alkyl.
地址 Chappaqua NY US