Arylosulfonamides for the treatment of CNS diseases

摘要

Arylsulphonamide derivatives of formula (I) and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of disorders of the central nervous system.;

主权项

1. A compound of the general formula (I) or pharmaceutically acceptable salt thereof, wherein E represents CH; represents single bond; n represents an integer from 2 to 6, inclusive; A is linked to E through one of its carbon atoms and is represented by the general formula (A1): wherein
R5 represents hydrogen atom, halogen atom or C1-C4-alkyl;Y represents NH, O or S;each of R1, R2, R3 and R4 independently represents hydrogen atom or halogen atom; D represents a group selected from:
unsubstituted phenyl or phenyl substituted with one or more substituents independently selected from the group consisting of branched C1-C4-alkyl; straight C1-C4-alkyl in ortho or meta position with respect to sulphonamide group; C1-C3-alkyloxy; halogeno-C1-C3-alkyl; halogeno-C1-C3-alkyloxy; halogen atom; —CN; —OH; and phenyl;unsubstituted naphthyl or naphthyl substituted with one or more substituents independently selected from the group consisting of C1-C4-alkyl; C1-C3-alkyloxy; halogeno-C1-C3-alkyl; halogen atom; —CN; —OH; and phenyl;5-membered aromatic heterocyclic group having 1 to 3 heteroatoms independently selected from the group consisting of N, O, S, the group being unsubstituted or substituted with one or more substituents independently selected from the group consisting of C1-C4-alkyl; C1-C3-alkyloxy; halogeno-C1-C3-alkyl; halogen atom; —CN; —OH; and phenyl;bicyclic group consisting of benzene or pyridine ring fused with 5-membered aromatic or non-aromatic heterocyclic ring having 1 to 3 heteroatoms independently selected from the group consisting of N, O, S, which group is unsubstituted or substituted with one or more substituents independently selected from the group consisting of C1-C4-alkyl; C1-C3-alkyloxy; halogeno-C1-C3-alkyl; halogen atom; ═O; —CN; —OH; and phenyl;bicyclic group consisting of benzene or pyridine ring fused with 6-membered non-aromatic heterocyclic ring having from 1 to 3 heteroatoms independently selected from the group consisting of N, O, S, which group is unsubstituted or substituted with one or more substituents independently selected from the group consisting of C1-C4-alkyl; C1-C3-alkyloxy; halogeno-C1-C3-alkyl; halogen atom; ═O; —CN; —OH; and phenyl.