| 主权项 |
1. A compound of Formula (III) or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C4-C10 cycloalkenyl, C(═O)R5, C(═O)OR5 and C(═O)NR5R5; V is selected from the group consisting of a bond, C(R4)2, C(R4)2C(R4)2, C(R4)2C(R4)2R6, C(R4)2C(R4)2C(R4)2R6, C(═O), C(═O)R6, C(═S), C(═S)R6, CH2C(═O), CH2C(═O)R6, CH2C(═S), CH2C(═S)R6, SO2, and SO2R6; A is a linking —C(Ra)2—Xa—; Xa is selected from the group consisting of O, C(R4)2O, OC(R4)2, NR5, C(═O), C(R4)2C(═O), C(═O)NR5, C(R4)2NR5, NR5C(R4)2, NR5C(═O), NR5C(═O)C(R4)2, S, C(R4)2S, and SC(R4)2;
when Xa is C(R4)2O, C(R4)2NR5, C(═O), C(R4)2C(═O), C(═O)NR5 or C(R4)2S, then each Ra is independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more R7, C2-C10 alkynyl, C2-C10 alkynyl substituted with one or more R7, C3-C10 cycloalkyl, C3-C10 cycloalkyl substituted with one or more R8, C4-C10 cycloalkenyl, C4-C10 cycloalkenyl substituted with one or more R8, halo, haloalkyl, OR5, SR5, NR5R5, C(═O)OR5, NO2, CN, C(═O)R5, C(═O)C(═O)R5, C(═O)NR5R5, N(R5)C(═O)R5, NR5S(═O)nR5, N(R5)C(═O)OR5, NR5C(═O)C(═O)R5, NR5C(═O)R5, NR5S(O)nNR5R5, NR5S(═O)nR5, S(═O)nR5, S(═O)nNR5R5 and OC(═O)R5, or both Ra are taken together to form a 3 to 6 membered ring containing 0 to 3 heteroatoms each independently selected from the group consisting of N, O and S, wherein said ring is substituted with one or more R8; and, when Xa is O, OC(R4)2, NR5, N5C(R4)2NR5C(═O), NC(═O)R5C(R4)2, S, or SC(R4)2, then each Ra is independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more R7, C2-C10 alkynyl, C2-C10 alkynyl substituted with one or more R7, C3-C10 cycloalkyl, C3-C10 cycloalkyl substituted with one or more R8, C4-C10 cycloalkenyl, C4-C10 cycloalkenyl substituted with one or more R8, haloalkyl, C(═O)OR5, CN, C(═O)R5, C(═O)C(═O)R5 and C(═O)NR5R5, or both Ra are taken together to form a 3 to 6 membered ring containing 0 to 3 heteroatoms each independently selected from the group consisting of N, O and S, wherein said ring is substituted with one or more R8; each R4 is independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more R7, C2-C10 alkynyl, C2-C10 alkynyl substituted with one or more R7, C3-C10 cycloalkyl, C3-C10 cycloalkyl substituted with one or more R8, C4-C10 cycloalkenyl, C4-C10 cycloalkenyl substituted with one or more R8, halo, haloalkyl, OR5, SR5, NR5R5, C(═O)OR5, NO2, CN, C(═O)R5, C(═O)C(═O)R5, C(═O)NR5R5, N(R5)C(═O)R5, NR5S(═O)nR5, NR5C(═O)OR5, NR5C(═O)C(═O)R5, NR5C(═O)R5, NR5S(═O)nNR5R5, NR5S(═O)nR5, S(═O)R5, S(═O)nNR5R5 and OC(═O)R5, or two R4 are taken together to form a 3-6 membered ring comprising 0-3 heteroatoms, wherein said heteroatom is independently selected from the group consisting of N, O and S, and wherein said ring is substituted with one or more R8; each R5 is independently selected from the group consisting of H, C1-C10 alkyl and C2-C10 alkenyl; each R6 is independently selected from the group consisting of C(R4)2, C(R4)2C(R4)2, NR5, O, C(═O), C(═O)C(R4)2, C(═O)O, OC(R4)2, C(R4)2O, C(R4)2S, C(R4)2NR5, NR5CH2, S and SC(R4)2; each R7 is independently selected from the group consisting of halo, haloalkyl, OR5, SR5, C(═O)R5, OC(═O)R5, C(═O)OR5, NR5R5, NO2, CN, OC(═O)NR5R5, C(═O)NR5R5, N(R5)C(═O)R5, NR5C(═O)OR5, S(═O)nNR5R5, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, 3-8 membered heterocycloalkyl, 4-10 membered heterocycloalkenyl, C5-C11 bicycloalkyl, C5-C11 bicycloalkenyl, 5-11 membered heterobicycloalkyl, 5-11 membered heterobicycloalkenyl, aryl, and heteroaryl, wherein said aryl and heteroaryl are each optionally substituted with one or more R9; each R8 is independently selected from the group consisting of R7, C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more R7, C2-C10 alkynyl, and C2-C10 alkynyl substituted with one or more R7; each R9 is independently selected from the group consisting of C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more R7, C2-C10 alkynyl, C2-C10 alkynyl substituted with one or more R7, C3-C10 cycloalkyl, C3-C10 cycloalkyl substituted with one or more R8, C4-C10 cycloalkenyl, C4-C10 cycloalkenyl substituted with one or more R8, 3-8 membered heterocycloalkyl, 3-8 membered eterocycloalkyl substituted with one or more R8, 4-10 membered heterocycloalkenyl, 4-10 membered heterocycloalkenyl substituted with one or more R8, C5-C11 bicycloalkyl, C5-C11 bicycloalkyl substituted with one or more R8, C5-C11 bicycloalkenyl, C5-C11 bicycloalkenyl substituted with one or more R8, 5-11 membered heterobicycloalkyl, 5-11 membered heterobicycloalkyl substituted with one or more R8, 5-11 membered heterobicycloalkenyl, 5-11 membered heterobicycloalkenyl substituted with one or more R8, halo, OR5, SR5, NR5R5, C(═O)OR5, NO2, CN, C(═O)R5, C(═O)C(═O)R5, C(═O)NR5R5, NR5C(═O)R5, NR5S(═O)nR5, NR5C(═O)OR5, NR5C(═O)C(═O)R5, NR5C(═O)NR5R5, NR5S(═O)nNR5R5, NR5S(═O)nR5, S(═O)nR5, S(═O)nNR5R5, OC(═O)R5, optionally substituted aryl, and optionally substituted heteroaryl; R12 is selected from the group consisting of:wherein in R12:
(a) W is selected from the group consisting of NR5, O and S; (b) each m is an integer from 0 to 3; (c) each p is an integer from 0 to 5; (d) each q is an integer from 0 to 4; (e) each t is an integer from 0 to 2; and (f) each R9 is independently selected from the group consisting of C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, halo, OR5, NR5R5, C(═O)OR5, NO2, CN, S(═O)nR5 optionally substituted aryl and optionally substituted heteroaryl; and each R13 independently selected from the group consisting of C1-C10 alkyl, C1-C10 alkyl substituted with one or more R7, C2-C10 alkenyl, C2-C10 alkenyl substituted with one or more R7, C2-C10 alkynyl, C2-C10 alkynyl substituted with one or more R7, C3-C10 cycloalkyl, C3-C10 cycloalkyl substituted with one or more R8, C4-C10 cycloalkenyl, C4-C10 cycloalkenyl substituted with one or more R8, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkyl substituted with one or more R8, 4-10 membered heterocycloalkenyl, 4-10 membered heterocycloalkenyl substituted with one or more R8, C5-C11 bicycloalkyl, C5-C11 bicycloalkyl substituted with one or more R8, C5-C11 bicycloalkenyl, C5-C11 bicycloalkenyl substituted with one or more R8, 5-11 membered heterobicycloalkyl, 5-11 membered heterobicycloalkyl substituted with one or more R8, 5-11 membered heterobicycloalkenyl, 5-11 membered heterobicycloalkenyl, 5-11 membered heterobicycloalkenyl substituted with one or more R8, halo, OR5, SR5, NR5R5, C(═O)OR5, NO2, CN, C(═O)R5, C(═O)C(═O)R5, C(═O)NR5R5, NR5C(═O)R5, NR5S(═O)nR5, NR5C(═O)OR5, NR5C(═O)C(═O)R5, NR5C(═O)NR5R5, NR5S(═O)nNR5R5, NR5S(═O)nR5, S(═O)nR5, S(═O)nNR5R5, OC(═O)R5, optionally substituted aryl and optionally substituted heteroaryl; n is 1 or 2; and q is an integer from 0 to 4. |
