Preparation of conjugates comprising adenine derivatives and allergenic proteins and their use for specific immunotherapy of allengenic diseases

摘要

The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases. (I, II).;

主权项

1. A stable conjugated compound of formula (II): wherein X═S; n is an number from 2-10; P is a protein, having antigenic activity which is bound through at least one lysine residue to (II); and m is a number ranging from 1 to the number of available lysine residues on said P protein.