| 发明名称 | Biopolymeric membranes | ||
| 摘要 | This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric. | ||
| 申请公布号 | US8821917(B2) | 申请公布日期 | 2014.09.02 |
| 申请号 | US201012897155 | 申请日期 | 2010.10.04 |
| 申请人 | Collagen Matrix, Inc. | 发明人 | Li Shu-Tung;Yuen Debbie;Hansen Peggy |
| 分类号 | A61F13/00;C07K14/78;B29C67/00;B29C67/24 | 主分类号 | A61F13/00 |
| 代理机构 | Cesari and McKenna, LLP | 代理人 | Cesari and McKenna, LLP |
| 主权项 | 1. A method of making an isotropic layer of cross-linked biopolymeric fibers, comprising: coacervating biopolymeric fibers having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; mechanically compressing the coacervated biopolymeric fibers into a layer; air-drying or freeze-drying the layer such that the layer has a density of 0.1 to 1.2 g/cm3; and cross-linking the biopolymeric fibers. | ||
| 地址 | Oakland NJ US | ||