发明名称 Heteroarylpiperidine and-piperazine derivatives as fungicides
摘要 Heteroarylpiperidine and -piperazine derivatives of the formula (I); in which the symbols are each as defined in the description, and agrochemically active salts thereof, and use thereof for controlling phytopathogenic harmful fungi, and also processes for preparing compounds of the formula (I).
申请公布号 US8822693(B2) 申请公布日期 2014.09.02
申请号 US201213364168 申请日期 2012.02.01
申请人 Bayer CropScience AG 发明人 Hoffmann Sebastian;Wasnaire Pierre;Tsuchiya Tomoki;Cristau Pierre;Seitz Thomas;Kluth Joachim;Benting Jürgen;Wachendorff-Neumann Ulrike
分类号 C07D417/14;A01N43/40;C07D417/04;A01N43/80 主分类号 C07D417/14
代理机构 Sterne, Kessler, Goldstein & Fox P.L.L.C. 代理人 Sterne, Kessler, Goldstein & Fox P.L.L.C.
主权项 1. A compound of formula (I), or a salt, a metal complex or a N-oxide thereof in which A is pyrazol-1-yl which is bonded to L1 and may contain up to four further substituents, where the substituents on carbon are each independently selected from ZA-2 and the substituents on nitrogen are each independently selected from ZA-3, ZA-2 and RG1 are the same or different and are each independently hydrogen, halogen, hydroxyl, thioxy, nitro, cyano, —C(═O)H, —CO(═O)H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, hydroxyalkyl, formylalkyl, alkoxyalkyl, alkylcarbonylalkyl, alkylcycloalkyl, alkoxy, alkylcycloalkylalkyl, alkylthio, haloalkylthio, alkynylthio, alkenyloxy, alkynyloxy, haloalkoxy, alkoxyalkoxy, alkylcarbonyloxy, halo alkylcarbonyloxy, cycloalkylcarbonylamino, alkylsulphonylamino, haloalkylsulphonylamino, phenylsulphonylamino, cycloalkylalkyl, halocycloalkylalkyl, cycloalkylcycloalkyl, alkoxycarbonyloxy, alkylcarbonylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyloxy, —C(═O)NR3R4 or —NR3R4, ZA-3 are the same or different and are each independently hydrogen, —C(═O)H, —C(═O)NR3R4, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylsulphonyl, haloalkylsulphonyl, cycloalkylsulphonyl, phenylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, cycloalkoxycarbonyl, phenyl or benzyl, R3, R4 and R7 are the same or different and are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, benzyl or phenyl, L1 is NRL12 or C(RL11)2, RL11 is the same or different and is independently hydrogen, halogen, hydroxyl, cyano, —C(═O)H, —CO(═O)H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, haloalkylthio, haloalkoxy, alkylcarbonyloxy, alkylcarbonylamino, alkylcarbonylthio, alkylsulphonyl, haloalkylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, trialkylsilyloxy, —NR3R4 or —C(═O)NR3R4, or the two RL11 radicals, together with the carbon atom to which they are bonded, form a cyclopropyl ring, or the two RL11 radicals are ═CH2, ═COR3, ═NOR3 or ═CHN(R3)2, RL12 is hydrogen, —C(═O)H, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylaminocarbonyl, haloalkylaminocarbonyl, alkylsulphonyl, haloalkylsulphonyl, cycloalkylsulphonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, cycloalkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, phenyl or benzyl, Y1 is oxygen, X is carbon, RX2 is hydrogen, R2 is oxo, alkyl, alkenyl, haloalkyl, alkoxy, halogen, cyano or hydroxyl, p is 0, 1 or 2, G is G1 or G3 where the bond identified by “v” is bonded directly to X and where the bond identified by “w” is bonded directly to Q1, Q1 is where the bond identified by “x” is bonded directly to G, and where the bond identified by “y” is bonded directly to —C(═Y2)—Y3—R1, RQ1 is bonded to carbon of the 5-membered heterocyclyl of Q1: hydrogen, oxo, halogen, cyano, hydroxyl, nitro, —CHO, —CO(═O)H, —C(═O)NH2, —C(═O)NR3R4, —NR3R4, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylcycloalkyl, halocycloalkylalkyl, alkylcycloalkylalkyl, cycloalkenyl, halocycloalkenyl, alkoxyalkyl, haloalkoxyalkyl, cycloalkoxyalkyl, alkoxyalkoxyalkyl, alkylthioalkyl, formylalkyl, alkylcarbonylalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, alkylaminoalkyl, dialkylaminoalkyl, haloalkylaminoalkyl, cycloalkylaminoalkyl, alkylcarbonyl, haloalkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkoxycarbonyl, cycloalkylalkoxycarbonyl, cycloalkylaminocarbonyl, hydroxyalkyl, alkoxy, haloalkoxy, cycloalkoxy, halocycloalkoxy, cycloalkylalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkoxyalkoxy, alkylcarbonyloxy, haloalkylcarbonyloxy, cycloalkylcarbonyloxy, alkylcarbonylalkoxy, alkylthio, haloalkylthio, cycloalkylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, halo alkylsulphonyl, cycloalkylsulphonyl, trialkylsilyl, alkylsulphonylamino, haloalkylsulphonylamino, phenyl or a 5- or 6-membered heteroaryl radical, where the phenyl or the 5- or 6-membered heteroaryl radical may bear up to two further substituents which are each independently selected from: alkenyl, alkenylamino, alkenyloxy, alkenylthio, alkynyl, alkynylamino, alkynyloxy, alkynylthio, alkoxy, alkoxyalkenyl, alkoxyalkynyl, alkoxyalkoxy, alkoxyalkoxyalkyl, alkoxyalkoxycarbonyl, alkoxyalkyl, alkoxyalkylaminocarbonyl, alkoxyalkylcarbonyl, alkoxyamino, alkoxycarbonyl, alkoxycarbonylalkoxy, alkoxycarbonylalkyl, alkoxycarbonylamino, alkoxyhaloalkoxy, alkoxyhaloalkyl, alkyl, alkylamino, alkylaminoalkyl, alkylaminocarbonyl, alkylaminocarbonylalkylamino, alkylaminocarbonylamino, alkylaminosuiphonyl, alkylaminothiocarbonyl, alkylaminothiocarbonylamino, alkylcarbonyl, alkylcarbonylalkoxy, alkylcarbonylamino, alkylcarbonyloxy, alkylcarbonylthio, alkylcycloalkyl, alkylcycloalkylalkyl, alkylsulphinyl, alkylsulphinylalkyl, alkylsulphonyl, alkylsulphonylalkyl, alkylsulphonylamino, alkylsulphonylaminocarbonyl, alkylthio, alkylthioalkyl, alkylthiocarbonyl, alkylthiocarbonyloxy, amino, aminocarbonyl, C(═N—OR7)R8, C(═O)NHCN, C(═O)OH, cyano, cyanoalkoxy, cyanoalkyl, cycloalkenyl, cycloalkenyloxyalkyl, cycloalkoxy, cycloalkoxyalkyl, cycloalkoxycarbonyl, cycloalkyl, cycloalkylalkoxy, cycloalkylalkoxycarbonyl, cycloalkylalkyl, cycloalkylalkylamino, cycloalkylalkylaminoalkyl, cyclo alkyl amino, cycloalkylaminoalkyl, cycloalkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylcarbonyloxy, cycloalkylcycloalkyl, cycloalkylsulphonyl, cycloalkylthio, dialkoxyalkyl, dialkylamino, dialkylaminoalkyl, dialkylaminocarbonyl, dialkylaminocarbonylamino, dialkylaminosulphonyl, dialkylaminothiocarbonyl, dialkylaminothiocarbonylamino, halogen, haloalkenyl, haloalkenyloxy, haloalkynyl, haloalkynyloxy, haloalkoxy, haloalkoxyalkoxy, haloalkoxyalkyl, haloalkoxyamino, haloalkoxycarbonyl, haloalkoxycarbonylamino, haloalkoxyhaloalkoxy, halo alkoxyhaloalkyl, haloalkyl, haloalkylamino, haloalkylaminoalkyl, haloalkylcarbonyl, haloalkylcarbonylamino, haloalkylcarbonyloxy, haloalkylsulphinyl, haloalkylsulphonyl, haloalkylsulphonylamino, haloalkylsulphonylaminocarbonyl, haloalkylthio, halocycloalkenyl, halocycloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkyl, halocycloalkylalkyl, halocycloalkylcarbonyloxy, halodialkylamino, halodialkylaminoalkyl, hydroxyl, hydroxyalkyl, NHCHO, NHCN, nitro, phenylsulphonylamino, SH, SF5, SO2NHCN, thioxy, trialkylsilyl, hydrogen; or RQ1 is bonded to nitrogen of the 5-membered heterocyclyl of Q1: hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, phenyl, benzyl, alkylsulphonyl, phenylsulphonyl, —C(═O)H, alkoxycarbonyl, benzyloxycarbonyl, alkylcarbonylalkyl or alkylcarbonyl, R8 is hydrogen, alkyl, alkenyl, haloalkyl, alkoxy, halogen, cyano or hydroxyl, Y2 is oxygen, Y3 is oxygen, sulphur or —(NRY3)—, RY3 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, cycloalkylalkyl, halocycloalkyl, benzyl, phenyl, NR3R4, alkylcarbonyl, alkyloxycarbonyl, alkylaminocarbonyl, trialkylsilyl, benzyloxycarbonyl, alkoxy, haloalkoxy, phenoxy or benzyloxy, R1 is substituted C3-C7-cycloalkyl, where the substituents are each independently selected from -Q2, Z1d, oxo and/or thioxo, Q2 is a phenyl ring which bears up to two substituents each independently selected from Z1f, or Q2 is a 5- or 6-membered heteroaryl radical which may contain up to two substituents, where the substituents are each independently selected from the following list: substituents on carbon: hydrogen, halogen, cyano, hydroxyl, formyl, SH, nitro, NR6R7, alkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylcycloalkyl, alkylcycloalkylalkyl, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxyalkyl, alkoxy, haloalkoxy, alkylcarbonyloxy, alkylcarbonylthio, alkylthio, haloalkylthio, alkylsulphinyl, haloalkylsulphinyl, alkylsulphonyl, haloalkylsulphonyl, trialkylsilyl or phenyl, substituents on nitrogen: hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkylcycloalkyl, cycloalkylalkyl, phenyl, benzyl, alkylsulphonyl, phenylsulphonyl, C(═O)H, alkoxycarbonyl, benzyloxycarbonyl, alkylaminocarbonyl, alkylcarbonylalkyl or alkylcarbonyl, R6 are the same or different and are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, benzyl, phenyl, alkylsulphonyl, phenylsulphonyl, alkoxycarbonyl, halo alkoxycarbonyl, benzyloxycarbonyl, alkylaminocarbonyl, alkylcarbonylalkyl, alkylcarbonyl, haloalkylcarbonyl or trialkylsilyl, Z1d is cyano, halogen, nitro, NR6R7, alkyl, haloalkyl, cycloalkyl, cycloalkylcycloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, trialkylsilyl, phenyl, hydroxyl, SH, oxo, alkoxy, alkoxyalkoxy, haloalkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkylalkyloxy, halocycloalkyloxy, halocycloalkylalkyloxy, alkoxycarbonyl, alkylcarbonyloxy, alkylcarbonyl, alkylthio or haloalkylthio, or phenoxy, Z1f is hydrogen, alkenyl, alkenylamino, alkenyloxy, alkenylthio, alkynyl, alkynylamino, alkynyloxy, alkynylthio, alkoxy, alkoxyalkenyl, alkoxyalkynyl, alkoxyalkoxy, alkoxyalkoxyalkyl, alkoxyalkoxycarbonyl, alkoxyalkyl, alkoxyalkylaminocarbonyl, alkoxyalkylcarbonyl, alkoxyamino, alkoxycarbonyl, alkoxycarbonylalkoxy, alkoxycarbonylalkyl, alkoxycarbonylamino, alkoxyhaloalkoxy, alkoxyhaloalkyl, alkyl, alkylamino, alkylaminoalkyl, alkylaminocarbonyl, alkylaminocarbonylalkylamino, alkylaminocarbonylamino, alkylaminosulphonyl, alkylaminothiocarbonyl, alkylaminothiocarbonylamino, alkylcarbonyl, alkylcarbonylalkoxy, alkylcarbonylamino, alkylcarbonyloxy, alkylcarbonylthio, alkylcycloalkyl, alkylcycloalkylalkyl, alkylsulphinyl, alkylsulphinylalkyl, alkylsulphonyl, alkylsulphonylalkyl, alkylsulphonylamino, alkylsulphonylaminocarbonyl, alkylthio, alkylthioalkyl, alkylthiocarbonyl, alkylthiocarbonyloxy, amino, aminocarbonyl, C(═N—OR7)R8, C(═O)H, C(═O)NHCN, CO(═O)H, cyano, cyanoalkoxy cyanoalkyl, cycloalkenyl, cycloalkenyloxyalkyl, cycloalkoxy, cycloalkoxyalkyl, cycloalkoxycarbonyl, cycloalkyl, cycloalkylalkoxy, cycloalkylalkoxycarbonyl, cycloalkylalkyl, cycloalkylalkylamino, cycloalkylalkylaminoalkyl, cycloalkyl amino, cycloalkylaminoalkyl, cycloalkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylcarbonyloxy, cycloalkylcycloalkyl, cycloalkylsulphonyl, cycloalkylthio, dialkoxyalkyl, dialkylamino, dialkylaminoalkyl, dialkylaminocarbonyl, dialkylaminocarbonylamino, dialkylaminosulphonyl, dialkylaminothiocarbonyl, dialkylaminothiocarbonylamino, halogen, haloalkenyl, haloalkenyloxy, haloalkynyl, haloalkynyloxy, haloalkoxy, haloalkoxyalkoxy, haloalkoxyalkyl, haloalkoxyamino, haloalkoxycarbonyl, haloalkoxycarbonylamino, haloalkoxyhaloalkoxy, haloalkoxyhaloalkyl, haloalkyl, haloalkylamino, haloalkylaminoalkyl, haloalkylcarbonyl, haloalkylcarbonylamino, haloalkylcarbonyloxy, haloalkylsulphinyl, haloalkylsulphonyl, haloalkylsulphonylamino, haloalkylsulphonylaminocarbonyl, halo alkylthio, halocycloalkenyl, halocycloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkyl, halocycloalkylalkyl, halocycloalkylcarbonyloxy, halodialkylamino, halodialkylaminoalkyl, hydroxyl, hydroxyalkyl, NHCHO, NHCN, nitro, phenylsulphonylamino, SH, SF5, SO2NHCN, thioxy, or trialkylsilyl, under the condition that the following compounds are excluded:
地址 Monheim DE