Hepatitis C virus inhibitors

摘要

This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

主权项

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
s is 0 or 1; L is -L1-L2-, wherein L1 and L2 are independently selected from:  provided that at least one of L1 and L2 is other than Y and Y′ are independently oxygen (O) or NH; R1 is hydrogen or —C(O)Rx; R2 is hydrogen or —C(O)Ry; Rx and Ry are independently selected from cycloalkyl, heteroaryl, heterocyclyl, alkoxy, and alkyl substituted with one or more substituents independently selected from aryl, alkenyl, cycloalkyl, heterocyclyl, heteroaryl, —OR3, —C(O)OR4, —NRaRb, and —C(O)NRcRd, wherein aryl and heteroaryl may optionally be substituted with one or more substituents independently selected from alkyl, haloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, halogen, cyano, nitro, —C(O)OR4, OR5, —NRaRb, (NRaRb)alkyl, and (MeO)(HO)P(O)O—, and wherein cycloalkyl and heterocyclyl may optionally be fused onto an aromatic ring and may optionally be substituted with one or more substituents independently selected from alkyl, hydroxyl, halogen, aryl, —NRaRb, oxo, and —C(O)OR4; R3 is hydrogen, alkyl, or arylalkyl; R4 is alkyl or arylalkyl; R5 is hydrogen, alkyl, or arylalkyl; Ra and Rb are independently selected from hydrogen, alkyl, cycloalkyl, arylalkyl, heteroaryl, —C(O)R6, —C(O)OR7, —C(O)NRcRd, and (NRcRd)alkyl, or alternatively, Ra and Rb, together with the nitrogen atom to which they are attached, form a five- or six-membered ring or bridged bicyclic ring structure, wherein said five- or six-membered ring or bridged bicyclic ring structure optionally may contain one or two additional heteroatoms independently selected from nitrogen, oxygen, and sulfur and may contain one, two, or three substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, aryl, hydroxyl, C1 to C6 alkoxy, C1 to C4 haloalkoxy, and halogen; R6 is alkyl; R7 is alkyl, arylalkyl, cycloalkyl, or haloalkyl; R100 and R110 are independently selected from hydrogen, alkyl, cyanoalkyl, and halo; Rc and Rd are independently selected from hydrogen, alkyl, arylalkyl, and cycloalkyl.