Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer

摘要

The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of a KDR-1121 or DC101 antibody, an extracellular hinge domain, a T cell receptor transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

主权项

1. A nucleic acid comprising a nucleotide sequence encoding a chimeric antigen receptor (CAR) comprising
(a) an antigen binding domain of a KDR-1121 or DC101 antibody, wherein the antigen binding domain comprises an amino acid sequence comprising SEQ ID NO: 1 or 2; (b) an amino acid sequence comprising SEQ ID NO: 3, 4, or 7; and (c) an amino acid sequence comprising SEQ ID NO: 5, 6, 8, or 9.