Method for electrostatic coating of a stent

摘要

A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.

主权项

1. A method of manufacturing a drug coated stent, comprising:
mounting a stent on a support structure, the stent being made from a polymeric material having insufficient conductivity for electrostatic coating; forming a treatment composition comprising a surfactant, and iodine, iodide, iodate, a complex or salt thereof; applying the treatment composition to a surface of the stent; applying a first charge to the stent or grounding the stent after the application of the treatment composition comprising the iodine, iodide, iodate, the complex or salt thereof to the surface of the stent; and applying a drug having a charge to the stent such that the drug is electrostatically deposited on the stent; wherein the surfactant is selected from the group consisting of polysorbate 20, polysorbate 60, polysorbate 80, Vitamin E TPGS, Poloxamer 407, Ascorbyl palmitate, gelatin, lecithin, egg yolk phopholipid, phosphatidylcholine, polyethylene glycol-phosphatidyl ethanolamine conjugate (PEG-PE), and combinations thereof.