Methods and compositions to treat myocardial conditions

摘要

Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

主权项

1. A method comprising:
delivering a structurally reinforcing agent to a ventricle wherein the structurally reinforcing agent comprises one or more solid material capable of increasing the compliance of the ventricle and comprises at least one of a surface component capable of reacting with another moiety and a property to recruit cells.