Apparatus and method for thermal assisted desorption ionization systems

摘要

The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

主权项

1. A device for analyzing an analyte comprising:
a spectrometer configured for analyzing the analyte, with an entrance for accepting analyte ions and a detector for detecting analyzed analyte ions; an atmospheric pressure source configured for generating ionizing species; a supply adapted to one or more of generate heat, transfer heat, conduct heat and radiate heat; and one or more mesh positioned between the source and the spectrometer, where the analyte is introduced on or near the one or more mesh, where the supply can one or more of generate heat, transfer heat, conduct heat and radiate heat to the analyte, where analyte molecules desorbed from the one or more mesh interact with the ionizing species generated by the source to form a plurality of analyte ions which enter the spectrometer and are analyzed.