Biaryl oxyacetic acid compounds

摘要

The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds provided include those of the general formula I:;

主权项

1. A compound of formula I or salt thereof wherein R1, R2, R3 and R4 are each independently selected from hydrogen and (C1-C6) alkyl; R5 is selected from hydrogen, (C1-C6) alkyl and (C3-C8) cycloalkyl; R6 is selected from:
a. (C1-C4) alkyl,b. (C3-C8) cycloalkyl,c. dialkylamino,d. alkylamino, ande. aryl, heteroaryl and arylalkyl, each optionally substituted with one to four substituents independently selected from halogen, cyano, (C1-C6) haloalkyl, (C1-C6) alkoxy, (C1-C6) haloalkoxy, (C1-C6) alkyl, and (C1-C6) alkylsulfonyl; R7a is selected from hydrogen and fluoro; R7b is selected from hydrogen, fluoro and chloro; R7c is selected from hydrogen, fluoro and chloro; A is selected from aryl and heteroaryl; and W, X, Y and Z are each independently selected from hydrogen, (C1-C6) alkyl, halogen, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, hydroxy, (C1-C6) alkoxyalkyl, (C1-C6) alkylsulfonyl, (C1-C6) alkylaminosulfonyl, carboxamido, cyano, (C1-C6) alkoxy, (C1-C6) alkoxycarbonyl, aminosulfonyl, dialkylaminosulfonyl, alkylaminocarbonyl, dialkylaminocarbonyl, heterocyclylcarbonyl, heterocyclylacyl, heterocyclylalkyl, and heterocyclyl optionally substituted with (C1-C6) alkyl; with the proviso that, when A is phenyl or pyridinyl substituted at the ortho position, any of W, X, Y and Z at said ortho position are each independently selected from hydrogen and halogen.