Compound containing basic group and use thereof

摘要

The present invention relates to a compound represented by formula (I-0):;
wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof.
;The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

主权项

1. A compound represented by formula (I-0): wherein A1 and A2 each independently represents an imidazole ring which may have a substituent(s); B1 and B2 each independently represents a methylene group which may have a substituent(s); E represents a phenylene which may have a substituent(s); L represents a —CO— or —CH2—; J0 represents 1-oxa-4,9-diazaspiro[5.5]undecane which may have a substituent(s); represents a single bond; D represents a nitrogen atom, G represents a —CO— or —CH2— or a salt thereof, an N-oxide thereof or a solvate thereof.