PIM kinase inhibitors and methods of their use

摘要

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

主权项

1. A compound of Formula III, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein, Z3 is CR2; R1 is selected from the group consisting of hydrogen, halo, alkyl, and —NHR3; each R2 is independently selected from the group consisting of hydrogen, halo, hydroxyl, and substituted or unsubstituted alkyl, alkoxy, amino, aryl, heteroaryl, cycloalkyl, and hetero cycloalkyl; and R3 is hydrogen.