| 发明名称 |
Pharmaceutical compositions |
| 摘要 |
A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier. |
| 申请公布号 |
US8821932(B2) |
申请公布日期 |
2014.09.02 |
| 申请号 |
US200712309294 |
申请日期 |
2007.06.29 |
| 申请人 |
|
发明人 |
Duncalf David John;Foster Alison Jayne;Long James;Rannard Steven Paul;Wang Dong |
| 分类号 |
A61K9/10;A61K31/351;A61K8/04;A61K9/16 |
主分类号 |
A61K9/10 |
| 代理机构 |
Michael Best & Friedrich LLP |
代理人 |
Michael Best & Friedrich LLP |
| 主权项 |
1. A process for the production of a non-porous, solid water-soluble composition comprising a water-insoluble statin which comprises the steps of:
a) providing an emulsion comprising:
i) a solution of the water-insoluble statin in a water-immiscible solvent for the same, andii) an aqueous solution of a water-soluble carrier material; and, b) spray-drying the emulsion to remove water and the water-immiscible solvent to obtain a substantially solvent-free nano-dispersion of the statin in the carrier material, wherein the particle size of the nanodisperse statin in the carrier material is between 15 nm and 800 nm. |
| 地址 |
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