N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors

摘要

This invention relates to compounds of formula I;
their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

主权项

1. A compound selected from the group consisting ofor a physiologically acceptable salt thereof.