发明名称 |
Methods and kits for the differential diagnosis of alzheimer' s disease versus frontotemporal dementia and for the diagnosis, assessing the severity, or monitoring progression of frontotemporal dementia, by using fas-l and ck18 biomarkers |
摘要 |
<p>The invention relates to methods and kits for the differential diagnosis of Alzheimer's disease (AD) versus frontotemporal dementia (FTD), using biomarkers TNF-α, FAS-L and CK18, taken from a biological sample. Differences in biomarker levels can be used to distinguish between AD and FTD The invention is based on a discovered correlation between FTD and markers FAS-L and CK18. Therefore the invention also relates to the diagnosis of FTD using FAS-L and CK18. The serum concentrations of these biomarkers can further be used as an index of the severity of disease, and may occur in conjunction with clinical-based diagnostic testing and neuro-imaging assessment.</p> |
申请公布号 |
IL208134(A) |
申请公布日期 |
2014.08.31 |
申请号 |
IL20100208134 |
申请日期 |
2010.09.14 |
申请人 |
MANUELA G. NEUMAN;MORRIS FREEDMAN |
发明人 |
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分类号 |
G01N |
主分类号 |
G01N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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