| 摘要 |
Disclosed is the use of an anti-TNFα antibody, or antigen-binding portion thereof, for the manufacture of a medicament for testing the efficacy of the anti-TNFα antibody, or antigen-binding portion thereof, for decreasing radiographic progression of joint disease associated with erosive polyarthritis wherein the testing comprises determining the efficacy of the anti TNFα antibody, or antigen-binding portion thereof, using a modified Total Sharp Score (mTSS) of a patient population having joint disease associated with erosive polyarthritis and a mTSS of the patient population following administration of the medicament, wherein no change or a decrease in the mTSS indicates that the anti-TNFα antibody, or antigen-binding portion thereof, is efficacious for decreasing radiographic progression of joint disease associated with erosive polyarthritis. |
