| 摘要 |
<p>THE SUBJECT INVENTION PROVIDES A PHARMACEUTICAL TABLET FORMULATION COMPRISING PER TABLET THE FOLLOWING INGREDIENTS: (A) A COMPOUND AS AN ACTIVE INGREDIENT, WHEREIN THE COMPOUND HAS A FORMULA: WHEREIN R IS SUBSTITUTED ADAMANTYL AND N IS AN INTEGER FROM 0 TO 3 OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF; (B) A HYDROXYPROPYL METHYLCELLULOSE WITH AN APPARENT VISCOSITY OF 80,000 CP TO 120,000 CP (NOMINAL VALUE 100,000 CP) WHEN PRESENT IN A 2% SOLUTION: (C) A MICROCRYSTALLINE CELLULOSE; AND (D) A MAGNESIUM STEARATE THE SUBJECT INVENTION ALSO PROVIDES A PHARMACEUTICAL TABLET FORMULATION, COMPRISING PER 400 MG TABLET THE FOLLOWING INGREDIENTS: (A) 1-[(3?HYDROXY-ADAMANT-1-YLAMINO)?ACETYL]-PYRROLIDINE?2 (S) ?CARBONITRILE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF; (B) A HYDROXYPROPYL METHYLCELLULOSE IN AN AMOUNT OF ABOUT 160 MG, WHEREIN THE HYDROXYPROPYL METHYLCELLULOSE HAS AN APPARENT VISCOSITY OF 80,000 CP TO 120,000 CP (NOMINAL VALUE 100,000 CP) WHEN PRESENT IN A 2% SOLUTION; (C) A MICROCRYSTALLINE CELLULOSE IN AN AMOUNT OF 120 MG; (D) A LACTOSE IN AN AMOUNT OF ABOUT 16 MG; AND (E) A MAGNESIUM STEARATE IN AN AMOUNT OF 4 MG. THE SUBJECT INVENTION ALSO PROVIDES A PHARMACEUTICAL TABLET FORMULATION COMPRISING PER TABLET THE FOLLOWING INGREDIENTS: (C) A COMPOUND AS AN ACTIVE INGREDIENT, WHEREIN THE COMPOUND HAS A FORMULA: WHEREIN R IS SUBSTITUTED ADAMANTYL AND N IS AN INTEGER FROM 0 TO 3; OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF; AND (D) A HYDROXYPROPY) METHYLCELLULOSE WITH AN APPARENT VISCOSITY OF 80,000 CP TO 120,000 CP (NOMINAL VALUE 100,000 CP) WHEN PRESENT IN A 2% SOLUTION.</p> |
