| 摘要 |
Disclosed is the use of a lipid carrier and at least two active agents in the preparation of a composition to treat otitis externa infection and sequelae thereof, wherein: - the lipid carrier is a lipid oil in water emulsion or a lipid micro emulsion or a lipid vesicle and the lipid is selected from phospholipids, phosphatidyl compounds, phosphatidylglycerol, phosphatidylinositol, phosphatidylcholine, 1,2-dia-cyl-5N-glycero-3-phosphatidyl choline, phosphatidylserine, phosphatidylethanolamine, sphingolipids, cerebrosides, gangliosides, diacylphosphatidylglycerols where the lipid moiety contains from 14-18 carbon atoms and is saturated, cardiolipins, trinoleins, lecithins and ceramides; and - the at least two active agents are selected from groups consisting of antibiotics, anti-fungals, anti-parasitics, anti-virals, non-steroidal anti-inflammatories, analgesics, anaesthetics and steroids, wherein the composition does not include viscosity-enhancing celluloses or a viscosity enhancing agent selected from alginic acid, gelatin, acacia carbomer and cetostearyl alcohol, or adhesive components, and the composition is not in the form of a gel, wherein the composition is for topical administration to the outer ear canal in a single dose sufficient to clinically ameliorate or resolve the treated condition. |
