发明名称 |
ANTI-AXL ANTIBODIES AND USES THEREOF |
摘要 |
<p>The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.</p> |
申请公布号 |
KR20140104944(A) |
申请公布日期 |
2014.08.29 |
申请号 |
KR20147001805 |
申请日期 |
2012.06.22 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);INSTITUT REGIONAL DU CANCER DE MONTPELLIER - VAL D'AURELLE;ORIBASE PHARMA;UNIVERSITE DE MONTPELLIER 1 |
发明人 |
ROBERT BRUNO;FAUVEL BENEDICTE;CHEVE GWENAEL;YASRI AZIZ;LARBOURET CHRISTEL;LECONET WILHEM;CHARDES THIERRY;LARROQUE CHRISTIAN;PELEGRIN ANDRE |
分类号 |
C07K16/28;A61K39/395;A61P7/00;A61P9/00;A61P31/00;A61P35/00;A61P37/04;C07K16/46;C12N15/09 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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