| 摘要 |
Disclosed is a conjugate comprising: a) a ligand for a glutathione transporter; and, b) a pharmaceutically acceptable nanocontainer containing a steroidal agent, wherein the nanocontainer is a nanocontainer selected from the group consisting of: A. a carrier protein; B. a liposome; C. a polyplex system; D. a lipoplex system; and E. polyethyleneglycol; and the ligand in a) is conjugated to at least one of the steroidal agent and the nanocontainer in b). Examples of a suitable a ligand for a glutathione transporter are glutathione, S-(p-bromobenzyl)glutathione, gamma-(L-gamma- azaglutamyl)-S-(p-bromobenzyl)-L-cysteinylglycin, S-butylglutathione, S-decylglutathione, glutathione reduced ethyl ester, glutathionesulfonic acid, S-hexylglutathione, S-lactoylglutathione, S-methylglutathione, S-(4-nitrobenzyl) glutathione, S-octylglutathione, S-propylglutathione, n-butanoyl gamma-glutamylcysteinylglycine, ethanoyl gamma-glutamylcysteinylglycine, hexanoyl gamma-glutamylcysteinylglycine, octanoyl gamma-glutamylcysteinylglycine, dodecanoyl gamma-glutamylcysteinylglycine, GSH monoisopropyl ester (N-(N-L-glutamyl-L-cysteinyl)glycine 1-isopropyl ester sulfate monohydrate) and glutathione derivatives. |
