发明名称 |
Substituted 6-amino-nicotinamides as kcnq2/3 modulators |
摘要 |
Provided are substituted 6-amino-nicotinamide compounds of the general formula (I) where the variables are defined in the specification. Examples of the compounds include N-[(3,5-Difluoro-phenyl)-methyl]-2-ethylsulfanyl-4-methyl-6-morpholin-4-ylpyridine-3-carboxylic acid amide and N-(4,4-Dimethyl-pentyl)-4-methyl-6-morpholin-4-yl-2-tetrahydro-pyran-4-ylpyridine-3-carboxylic acid amide. The compounds are modulators of voltage gated potassium (K+) channels KCNQ2/3 (Kv7.2/7.3). Further provided are pharmaceutical compositions comprising the compounds and methods of treating pain and neurological disorders. |
申请公布号 |
NZ610689(A) |
申请公布日期 |
2014.08.29 |
申请号 |
NZ20110610689 |
申请日期 |
2011.10.19 |
申请人 |
GRUNENTHAL GMBH |
发明人 |
KÜHNERT SVEN;BAHRENBERG GREGOR;KLESS ACHIM;SCHRÖDER WOLFGANG;LUCAS SIMON |
分类号 |
C07D213/82;A61K31/44;A61K31/4427;A61K31/4545;A61K31/496;A61K31/5377;A61K31/553;A61P25/00;C07D401/04;C07D401/14;C07D405/12;C07D413/04;C07D413/14 |
主分类号 |
C07D213/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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