Heterocyclic compounds and uses therof

摘要

Chemical entities that modulate phosphatidylinositide 3-kinase (PI3K) activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PO kinase activity are described herein. compounds of the disclosure include: (S)-3-(1-(9H-purin-6-ylamino)ethyl)-2-cyclopropyl-8-methylisoquinolin-1(2H)-one, and (S)-3-(1-(9H-purin-6-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one.