发明名称 |
Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto. |
摘要 |
This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer. |
申请公布号 |
CL2014000159(A1) |
申请公布日期 |
2014.08.29 |
申请号 |
CL20140000159 |
申请日期 |
2014.01.21 |
申请人 |
INNOCORE TECHNOLOGIES B.V. |
发明人 |
STEENDAM ROB;FLIPSEN THEODORUS ADRIANUS CORNELIUS;HIEMSTRA CHRISTINE;ZUIDEMA JOHAN |
分类号 |
A61K9/16;C08G81/00;C08L87/00 |
主分类号 |
A61K9/16 |
代理机构 |
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