SYSTEM AND METHOD FOR ESTIMATING GLUCOSE IN PLASMA

摘要

A plasma glucose estimation system is provided comprising a sensor which generates a signal from a glucose concentration measured in a medium, filtering means and a glycemic estimator. Also a method comprising: i) generating a signal which represents the glucose concentration measured in the medium; ii) filtering the signal generated; iii) applying a set of local estimation models, to the previous signal, obtaining a set of local plasma glucose estimates; iv) applying a weighting to each one of the local estimates previously obtained; v) estimating a plasma glucose concentration by the sum of the weighted local estimates obtained in the previous step; vi) correcting the signal obtained from the previous step from reference glycemia measurements and obtaining the final plasma glucose estimate.

主权项

1. A plasma glucose estimation system comprising:
a sensor operative to generate a monitoring signal selected from a current intensity signal and an alternative signal from a glucose concentration measured in a medium selected from an interstitial fluid and a remote compartment; filtering means operative to filter the monitoring signal; and, a glycemic estimator comprising at least:
two local estimation modules, where each local estimation module calculates a local plasma glucose estimate from reference glycemia measurements and from the monitoring signal generated by the sensor previously filtered through the filtering means;a local weighting module for each local estimation module connected in series,where each local weighting module weights the local plasma glucose estimate calculated by the local estimation module whereto it is connected; andan adder comprising one input for each local weighting module connected to each output of each local weighting module;such that the glycemic estimator calculates an overall estimate of plasma glucose resulting from the sum of the weightings carried out by the local weighting modules.