Compositions and Methods for Diagnosing Hypercoagulability and Hypocoagulability

摘要

The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion.

主权项

1. A method of diagnosing hypercoagulability associated with carbon monoxide exposure in a subject, the method comprising:
a. obtaining a plasma sample from the subject, and b. dividing the plasma sample into at least two portions, and c. determining the clot strength of a first portion of the plasma sample, and d. exposing a second portion of the plasma sample to an effective amount of an organic reductant, and e. determining the clot strength of the second portion of the plasma sample after exposure to the effective amount of the organic reductant, and f. comparing the clot strength of the first portion of the plasma sample with the clot strength of the second portion of the plasma sample, wherein when the clot strength of the second portion of the plasma sample is decreased compared with the clot strength of the first portion of the plasma sample, the subject is diagnosed with hypercoagulability associated with carbon monoxide exposure.