发明名称 COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS
摘要 Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.
申请公布号 US2014242026(A1) 申请公布日期 2014.08.28
申请号 US201414272689 申请日期 2014.05.08
申请人 Aerpio Therapeutics Inc. 发明人 Shalwitz Robert;Peters Kevin Gene
分类号 C07D277/28;A61K38/20;A61K31/7068;A61K31/517;A61K31/65;A61K31/4375;A61K39/395;A61K31/426;C07D417/04;A61K31/427;A61K31/497;A61K31/4439;C07D277/64;A61K31/428;C07D417/12;C07D417/14;A61K31/538;A61K31/337 主分类号 C07D277/28
代理机构 代理人
主权项 1. A method for reducing the volume of a tumor in a subject, comprising administering to the subject a compound of the formula: wherein R is a thiazolyl unit having the formula: R2 and R4 are each chosen from: i) substituted or unsubstituted C1-C6 linear, C3-C6 branched, or C3-C6 cyclic alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted thiophenyl; R1 is C1-C6 linear, C3-C6 branched or C3-C6 cyclic alkoxy; or a pharmaceutically acceptable salt thereof.
地址 Cincinnati OH US