| 发明名称 |
BICYCLO 2,3-BENZODIAZEPINES AND SPIROCYCLICALLY SUBSTITUTED 2,3-BENZODIAZEPINES |
| 摘要 |
The invention relates to BET protein-inhibiting, in particular BRD4-inhibiting, bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), to the pharmaceutical agents containing the compounds according to the invention, and to the prophylactic and therapeutic use thereof against hyper-proliferative diseases, in particular tumor diseases. The invention further relates to the use of BET protein inhibitors in benign hyperplasia, atherosclerotic diseases, sepsis, autoimmune diseases, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, and male fertility control. |
| 申请公布号 |
WO2014128067(A1) |
申请公布日期 |
2014.08.28 |
| 申请号 |
WO2014EP52984 |
申请日期 |
2014.02.17 |
| 申请人 |
BAYER PHARMA AKTIENGESELLSCHAFT |
发明人 |
SIEGEL, STEPHAN;BÄURLE, STEFAN;CLEVE, ARWED;HAENDLER, BERNARD;FERNÁNDEZ-MONTALVÁN, AMAURY ERNESTO;MÖNNING, URSULA;KRAUSE, SABINE;LEJEUNE, PASCALE;BUSEMANN, MATTHIAS;KUHNKE, JOACHIM |
| 分类号 |
C07D401/10;A61K31/551;A61P7/00;A61P25/28;A61P31/12;A61P35/00;A61P37/00;C07D403/10;C07D405/10;C07D451/06;C07D471/10;C07D487/04;C07D487/08;C07D487/10;C07D491/048 |
主分类号 |
C07D401/10 |
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